Skip NavigationSkip to Content
Return Return to Search Results

Alpha globin gene copy number and incident ischemic stroke risk among Black Americans

  1. Author:
    Ruhl, A Parker
    Jeffries, Neal
    Yang, Yu
    Brooks, Steven D
    Naik, Rakhi P
    Pecker, Lydia H
    Mott, Bryan T
    Winkler,Cheryl
    Armstrong, Nicole D
    Zakai, Neil A
    Gutierrez, Orlando M
    Judd, Suzanne E
    Howard, Virginia J
    Howard, George
    Irvin, Marguerite R
    Cushman, Mary
    Ackerman, Hans C

  2. Author Address

    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland., Pulmonary Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland., Office of Biostatistics Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland., Division of Blood Diseases and Resources, National Heart, Lung, and Blood Institute, Rockville, Maryland., Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland., Wake Forest University School of Medicine, Winston-Salem, North Carolina., Basic Research Laboratory, National Cancer Institute, Frederick National Laboratory for Cancer Research, Frederick, Maryland., Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama., Department of Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont., Department of Pathology & Laboratory Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont., Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.,
    1. Year: 2023
    2. Epub Date: 2023 06 15
  2. Journal: Frontiers in Stroke
    1. 2
  4. Type of Article: Article
  5. Article Number: 1192465
  1. Abstract:

    People with African ancestry have greater stroke risk and greater heritability of stroke risk than people of other ancestries. Given the importance of nitric oxide (NO) in stroke, and recent evidence that alpha globin restricts nitric oxide release from vascular endothelial cells, we hypothesized that alpha globin gene (HBA) deletion would be associated with reduced risk of incident ischemic stroke. We evaluated 8,947 participants self-reporting African ancestry in the national, prospective Reasons for Geographic And Racial Differences in Stroke (REGARDS) cohort. Incident ischemic stroke was defined as non-hemorrhagic stroke with focal neurological deficit lasting = 24 hours confirmed by the medical record or focal or non-focal neurological deficit with positive imaging confirmed with medical records. Genomic DNA was analyzed using droplet digital PCR to determine HBA copy number. Multivariable Cox proportional hazards regression was used to estimate the hazard ratio (HR) of HBA copy number on time to first ischemic stroke. Four-hundred seventy-nine (5.3%) participants had an incident ischemic stroke over a median (IQR) of 11.0 (5.7, 14.0) years' follow-up. HBA copy number ranged from 2 to 6: 368 (4%) -a/-a, 2,480 (28%) -a/aa, 6,014 (67%) aa/aa, 83 (1%) aaa/aa and 2 (< 1%) aaa/aaa. The adjusted HR of ischemic stroke with HBA copy number was 1.04; 95%CI 0.89, 1.21; p = 0.66. Although a reduction in HBA copy number is expected to increase endothelial nitric oxide signaling in the human vascular endothelium, HBA copy number was not associated with incident ischemic stroke in this large cohort of Black Americans.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.3389/fstro.2023.1192465
  3. PMID: 37622047
  4. PMCID: PMC10448705
  5. PII : 1192465

Library Notes

  1. Fiscal Year: FY2022-2023
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel