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Molecular cloning of a novel type 1 cytokine receptor similar to the common gamma chain

  1. Author:
    Fujio, K.
    Nosaka, T.
    Kojima, T.
    Kawashima, T.
    Yahata, T.
    Copeland, N. G.
    Gilbert, D. J.
    Jenkins, N. A.
    Yamamoto, K.
    Nishimura, T.
    Kitamura, T.

  2. Author Address

    Kitamura T Univ Tokyo, Inst Med Sci, Dept Hematopoiet Factors, Minato Ku 4-6-1 Shirokanedai Tokyo 1088639 Japan Univ Tokyo, Inst Med Sci, Dept Hematopoiet Factors, Minato Ku Tokyo 1088639 Japan Tokai Univ, Sch Med, Dept Immunol Isehara Kanagawa 25911 Japan NCI, Mammalian Genet Lab, ABL, Basic Res Program,Frederick Canc Res & Dev Ctr Frederick, MD 21701 USA Univ Tokyo, Grad Sch Med, Dept Allergy & Rheumatol Tokyo Japan
    1. Year: 2000
  2. Journal: Blood
    1. 95
    2. 7
    3. Pages: 2204-2211
  4. Type of Article: Article
  1. Abstract:

    In a complementary DNA (cDNA) screening of murine Th2-skewed lymphocytes with our recently developed signal sequence trap method termed SST-REX, a novel type 1 cytokine receptor, Delta1 (delta 1), was identified. Although delta 1 is ubiquitously expressed in multiple tissues, the expression level is higher in Th2-skewed lymphocytes than in Th1-skewed ones. The delta 1 cDNA encodes a 359-amino acid type I membrane protein. The extracellular domain of 206 amino acids showed 24% identity with the murine common gamma receptor that is shared among the receptors for interleukin(IL)-2, IL-4, IL-7, IL-9, and IL-15. The membrane-proximal region of delta 1 includes a box1 motif, which is important for association with Janus kinases (JAKs), and showed a significant homology with that of the mouse erythropoietin receptor (EPOR). A box2 motif was also found in close proximity to the box1 region. Dimerization of the cytoplasmic region of delta 1 alone did not transduce proliferative signals in IL-3-dependent cell lines, However, the membrane-proximal region of delta 1 could substitute for that of human EPOR in transmitting proliferative signals and activating JAK2. These results suggest that delta 1 is a subunit of cytokine receptor that may be involved in multiple receptor systems and play a regulatory role in the immune system and hematopoiesis, (Blood, 2000; 95:2204-2211) (C) 2000 by The American Society of Hematology. [References: 54]

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