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Regulation of P311 expression by Met-hepatocyte growth factor/scatter factor and the ubiquitin/proteasome system

  1. Author:
    Taylor, G. A.
    Hudson, E.
    Resau, J. H.
    Vande Woude, G. F.

  2. Author Address

    Vande Woude GF Van Andel Res Inst 201 Monroe Ave NW,Suite 400 Grand Rapids, MI 49503 USA Adv Biosci Labs, Basic Res Program Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr Frederick, MD 21702 USA
    1. Year: 2000
  2. Journal: Journal of Biological Chemistry
    1. 275
    2. 6
    3. Pages: 4215-4219
  4. Type of Article: Article
  1. Abstract:

    P311 is a mouse cDNA originally identified for its high expression in late-stage embryonic brain and adult cer ebellum, hippocampus, and olfactory bulb. The protein product of P311, however, had not been identified previously, and its function remains unknown. We report here that P311 expression is regulated at multiple levels by pathways that control cellular transformation. P311 mRNA expression was decreased sharply in both neural and smooth muscle cells when the cells were transformed by coexpression of the oncogenic tyrosine kinase receptor Met and its ligand hepatocyte growth factor/scatter factor. The P311 mRNA was found to encode an 8-kDa polypeptide that was subject to rapid degradation by the lactacystin-sensitive ubiquitin/proteasome system and an unidentified metalloprotease, resulting in a protein half-life of about 5 min. These data suggest that P311 expression is dramatically decreased by several pathways that regulate cellular growth. [References: 23]

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