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Effects of growth hormone and prolactin on hematopoiesis

  1. Author:
    Welniak, L. A.
    Tian, Z. G.
    Sun, R.
    Keller, J. R.
    Richards, S.
    Ruscetti, F. W.
    Murphy, W. J.

  2. Author Address

    Murphy WJ NCI, Frederick Canc Res & Dev Ctr, SAIC, IRSP Bldg 567,Rm 210 Ft Detrick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, SAIC, IRSP Ft Detrick, MD 21702 USA
    1. Year: 2000
  2. Journal: Leukemia & Lymphoma
    1. 38
    2. 5-6
    3. Pages: 435-445
  4. Type of Article: Review
  1. Abstract:

    The use of the neuroendocrine hormones growth hormone (GH) and prolactin (PRL) in preclinical models, demonstrating promotion of hematopoietic recovery and immune function, offers promise for several clinical situations. These hormones do not appear to produce the same extent of immune/hematopoietic effects when compared to conventional hematopoietic and immune stimulating cytokines (i.e. G-CSF or interleukin-2). However, their pleiotropic effects and limited toxicity after systemic administration makes them attractive to test in myeloablative situations. More work needs to be performed to understand the mechanism(s) of GH and PRL action, particularly with regard to hematopoietic progenitor cell expansion and differentiation both in normal and pathologic situations. [References: 40]

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