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Lsh, a SNF2 family member, is required for normal murine development

  1. Author:
    Geiman, T. M.
    Tessarollo, L.
    Anver, M. R.
    Kopp, J. B.
    Ward, J. M.
    Muegge, K.

  2. Author Address

    NCI, Frederick Canc Res & Dev Ctr, Mol Immunoregulat Lab, SAIC, Bldg 469, Rm 239, Frederick, MD 21702 USA. NCI, Frederick Canc Res & Dev Ctr, Mol Immunoregulat Lab, SAIC, Frederick, MD 21702 USA. NCI, Mammalian Genet Lab, Frederick, MD 21702 USA. NCI, Frederick Canc Res & Dev Ctr, Pathol Histotechnol Lab, SAIC, Frederick, MD 21702 USA. NIDDKD, Kidney Dis Sect, Bethesda, MD 21702 USA. NCI, Vet & Tumor Pathol Sect, Off Lab Anim Resources, Frederick, MD 21702 USA. Muegge K NCI, Frederick Canc Res & Dev Ctr, Mol Immunoregulat Lab, SAIC, Bldg 469, Rm 239, Frederick, MD 21702 USA.
    1. Year: 2001
  2. Journal: Biochimica Et Biophysica Acta-General Subjects
    1. 1526
    2. 2
    3. Pages: 211-220
  4. Type of Article: Article
  1. Abstract:

    Lsh is a member of the SNF2 family of chromatin remodelers, that regulate diverse biological processes such as replication, repair and transcription. Although expression of Lsh is highly tissue specific in adult animals, Lsh mRNA is detectable in multiple tissues during embryogenesis. In order to determine the physiologic role of Lsh during murine development and to assess its unique function in adult mice, we performed targeted deletion of the Lsh gene using homologous recombination in murine embryonic stem cells. Lsh-/- embryos occurred with the expected Mendelian frequency after implantation and during embryogenesis. However, Lsh-/- mice died within a few hours after birth. Furthermore, newborn mice were 22% lower in weight in comparison with their littermates and showed renal lesions. Thus Lsh is a non-redundant member of the SNF2 family and is essential for normal murine development and survival. (C) 2001 Elsevier Science B.V. All rights reserved.

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