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Pleiotropic roles of formyl peptide receptors

  1. Author:
    Le, Y. Y.
    Oppenheim, J. J.
    Wang, J. M.

  2. Author Address

    Natl Canc Inst, Div Basic Sci, Mol Immunoregulat Lab, Frederick, MD 21702 USA. Natl Canc Inst, Div Basic Sci, Mol Immunoregulat Lab, Frederick, MD 21702 USA. Le YY Natl Canc Inst, Div Basic Sci, Mol Immunoregulat Lab, Frederick, MD 21702 USA.
    1. Year: 2001
  2. Journal: Cytokine & Growth Factor Reviews
    1. 12
    2. 1
    3. Pages: 91-105
  4. Type of Article: Article
  1. Abstract:

    FPR and FPRL1 belong to the seven-transmembrane, G protein- coupled chemoattractant receptor superfamily. Because of their capacity to interact with bacterial chemotactic formylated peptides. these receptors are thought to play a role in host defense against microbial infection. Recently, a variety of novel agonists have been identified for these receptors, including several host-derived endogenous molecules that are involved in proinflammatory responses. Most notably is the use of FPRL1 by at least three amyloidogenic protein and peptide ligands, the serum amyloid A (SAA), the 42 amino acid form of beta amyloid (A beta (42)), and the prion peptide PrP106-126, to chemoattract and activate human phagocytic leukocytes. These new findings have greatly expanded the functional scope of the formyl peptide receptors and call for more in-depth investigation of the role of these receptors in pathophysiological conditions. (C) 2001 Published by Elsevier Science Ltd.

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