Skip NavigationSkip to Content
Return Return to Search Results

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon gamma-dependent natural killer cell protection from tumor metastasis

  1. Author:
    Smyth, M. J.
    Cretney, E.
    Takeda, K.
    Wiltrout, R. H.
    Sedger, L. M.
    Kayagaki, N.
    Yagita, H.
    Okumura, K.

  2. Author Address

    Peter MacCallum Canc Inst, Locked Bag 1, ABeckett St, Melbourne, Vic 8006, Australia. Juntendo Univ, Sch Med, Dept Immunol, Bunkyo Ku, Tokyo 1138421, Japan. Univ Sydney, Dept Pathol, Sydney, NSW 2006, Australia. NCI, Frederick Canc Res & Dev Ctr, Expt Immunol Lab, Div Basic Sci, Frederick, MD 21702 USA. Peter MacCallum Canc Inst, Sir Donald & Lady Trescowthick Labs, E Melbourne, Vic 3002, Australia. Smyth MJ Peter MacCallum Canc Inst, Locked Bag 1, ABeckett St, Melbourne, Vic 8006, Australia.
    1. Year: 2001
  2. Journal: Journal of Experimental Medicine
    1. 193
    2. 6
    3. Pages: 661-670
  4. Type of Article: Article
  1. Abstract:

    Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is expressed by in vitro activated natural killer (NK) cells, but the relevance of this observation to the biological function of NK cells has been unclear. Herein, we have demonstrated the in vivo induction of mouse TRAIL expression on various tissue NK cells and correlated NK cell activation with TRAIL-mediated antimetastatic function in vivo. Expression of TRAIL was only constitutive on a subset of liver NK cells, and innate NK cell control of Renca carcinoma hepatic metastases in the liver was partially TRAIL dependent. Administration of therapeutic doses of interleukin (IL)-12, a powerful inducer of interferon (IFN)-gamma production by NK cells and NKT cells, upregulated TRAIL expression on liver, spleen, and lung NK cells, and IL-12 suppressed metastases in both liver and lung in a TRAIL-dependent fashion. By contrast, alpha - galactosylceramide (alpha -GalCer), a powerful inducer of NKT cell IFN-gamma and IL-4 secretion, suppressed both liver and lung metastases but only stimulated NK cell TRAIL-mediated function in the liver. TRAIL. expression was not detected on NK cells from IFN-gamma -deficient mice and TRAIL-mediated antimetastatic effects of IL-12 and a-GalCer were strictly IFN- gamma dependent. These results indicated that TRAIL induction on NK cells plays a critical role in IFN-gamma -mediated antimetastatic effects of IL-12 and alpha -GalCer.

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel