Skip NavigationSkip to Content
Return Return to Search Results

A novel anti-HIV macrocyclic peptide from Palicourea condensata

  1. Author:
    Bokesch, H. R.
    Pannell, L. K.
    Cochran, P. K.
    Sowder, R. C.
    McKee, T. C.
    Boyd, M. R.

  2. Author Address

    NCI, Lab Drug Discovery Res & Dev, Div Basic Sci, Frederick, MD 21702 USA. NCI, Lab Drug Discovery Res & Dev, Div Basic Sci, Frederick, MD 21702 USA. SAIC Frederick, AIDS Vaccine Program, Frederick, MD 21702 USA. NIDDK, Bioorgan Chem Lab, NIH, Bethesda, MD 20892 USA. Boyd MR NCI, Lab Drug Discovery Res & Dev, Div Basic Sci, Frederick, MD 21702 USA.
    1. Year: 2001
  2. Journal: Journal of Natural Products
    1. 64
    2. 2
    3. Pages: 249-250
  4. Type of Article: Article
  1. Abstract:

    A 37 amino acid cyclic polypeptide has been isolated from the organic extract of the tropical tree Palicourea condensata. Palicourein (1) is the largest of a growing family of plant peptides that contain a cyclized amino acid backbone cross- linked via three internal disulfide bridges. Palicourein inhibits the in vitro cytopathic effects of HIV-1(RF) infection of CEM-SS cells with an EC50 value of 0.1 muM and an IC50 value of 1.5 muM.

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel