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LUCA-15 suppresses CD95-mediated apoptosis in Jurkat T cells

  1. Author:
    Sutherl, L. C.
    Lerman, M.
    Williams, G. T.
    Miller, B. A.

  2. Author Address

    Sigfried & Janet Weis Ctr Res, Geisinger Clin, Henry Hood Res Program, 100 N Acad Ave, Danville, PA 17822 USA. Sigfried & Janet Weis Ctr Res, Geisinger Clin, Henry Hood Res Program, Danville, PA 17822 USA. Penn State Univ, Milton S Hershey Med Ctr, Coll Med, Dept Pediat, Div Hematol Oncol, Hershey, PA 17033 USA. NCI, Immunobiol Lab, FCRDC, Frederick, MD 21702 USA. Univ Keele, Sch Life Sci, Keele ST5 5BG, Staffs, England. Sutherland LC Sigfried & Janet Weis Ctr Res, Geisinger Clin, Henry Hood Res Program, 100 N Acad Ave, Danville, PA 17822 USA.
    1. Year: 2001
  2. Journal: Oncogene
    1. 20
    2. 21
    3. Pages: 2713-2719
  4. Type of Article: Article
  1. Abstract:

    The candidate tumour suppressor gene, LUCA-15, maps to the lung cancer tumour suppressor locus 3p21.3. Overexpression of an alternative RNA splice variant of LUCA-15 has been shown to retard human Jurkat T cell proliferation and to accelerate CD95-mediated apoptosis, An antisense cDNA to the 3'-UTR of this splice variant was able to suppress CD95-mediated apoptosis, Here, we report that overexpression of LUCA-15 itself suppresses CD95-mediated apoptosis in Jurkat cells. This suppression occurs Drier to the final execution stage of the CD95 signalling pathway, and is associated with upregulation of the apoptosis inhibitory protein Bcl-2, LUCA-15 overexpression is also able to inhibit apoptosis induced by the protein kinase inhibitor staurosporine, but is not able to significantly suppress apoptosis mediated by the topoisomerase II inhibitor etoposide, These findings suggest that LUCA-15 is a selective inhibitor of cell death, and confirm the importance of the LUCA-15 genetic locus in the control of apoptosis.

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