Skip NavigationSkip to Content
Return Return to Search Results

Entry of influenza virus into a glycosphingolipid-deficient mouse skin fibroblast cell line

  1. Author:
    Ablan, S.
    Rawat, S. S.
    Blumenthal, R.
    Puri, A.

  2. Author Address

    NCI, LECB, CCR, NIH, POB B, Bldg 469, Rm 211, Miller Dr, Frederick, MD 21702 USA. NCI, LECB, CCR, NIH, Frederick, MD 21702 USA. Puri A NCI, LECB, CCR, NIH, POB B, Bldg 469, Rm 211, Miller Dr, Frederick, MD 21702 USA.
    1. Year: 2001
  2. Journal: Archives of Virology
    1. 146
    2. 11
    3. Pages: 2227-2238
  4. Type of Article: Article
  1. Abstract:

    A glycosphingolipid (GSL)-deficient mouse skin fibroblast mutant cell line (GM95) was tested for its susceptibility to influenza virus infection and/or fusion. Octadecyl rhodamine labeled influenza virus fused at 37 degreesC and low pH with GM95 cells at similar rates and extents as with the parental cell lines which did bear glycosphingolipids. Influenza virus infected the GM95 cells at the same level as the parental cell lines. The infection and fusion was blocked when the cell lines were pre-treated with neuramindase. We conclude that influenza virus uses mainly sialoglycoproteins and that gangliosides are not essential for influenza virus fusion and infection.

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel