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Specifically targeting the CD22 receptor of human B-cell lymphomas with RNA damaging agents

  1. Author:
    Newton, D. L.
    Hansen, H. J.
    Liu, H. T.
    Ruby, D.
    Iordanov, M. S.
    Magun, B. E.
    Goldenberg, D. M.
    Rybak, S. M.

  2. Author Address

    NCI, Frederick Canc Res & Dev Ctr, Screening Technol Branch, Dev Therapeut Program, Div Canc Treatment & Diag, Bldg 567, Room 162, Frederick, MD 21702 USA. NCI, Frederick Canc Res & Dev Ctr, Screening Technol Branch, Dev Therapeut Program, Div Canc Treatment & Diag, Frederick, MD 21702 USA. NCI, Frederick Canc Res & Dev Ctr, SAIC Frederick, Frederick, MD 21702 USA. Immunomed, Morris Plains, NJ 07950 USA. Oregon Hlth Sci Univ, Dept Cell & Dev Biol, Portland, OR 97201 USA. Garden State Canc Ctr, Belleville, NJ 07109 USA. Rybak SM NCI, Frederick Canc Res & Dev Ctr, Screening Technol Branch, Dev Therapeut Program, Div Canc Treatment & Diag, Bldg 567, Room 162, Frederick, MD 21702 USA.
    1. Year: 2001
  2. Journal: Critical Reviews in Oncology Hematology
    1. 39
    2. 1-2
    3. Pages: 79-86
  4. Type of Article: Article
  1. Abstract:

    Targeting CD22 on human B-cells with a monoclonal antibody conjugated to a cytotoxic RNAse causes potent and specific killing of the lymphoma cells in vitro. This translates to anti-tumor effects in human lymphoma models in SCID mice. RNA damage caused by RNAses could be an important alternative to standard DNA damaging chemotherapeutics. Moreover, targeted RNAses may overcome problems of toxicity and immunogenicity associated with plant or bacterial toxin containing immunotoxins. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

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