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The 4-oxopentyl group as a labile phosphate/thiophosphate protecting group for synthetic oligodeoxyribonucleotides

  1. Author:
    Wilk, A.
    Chmielewski, M. K.
    Grajkowski, A.
    Phillips, L. R.
    Beaucage, S. L.

  2. Author Address

    US FDA, Ctr Biol Evaluat & Res, 8800 Rockville Pike, Bethesda, MD 20892 USA. US FDA, Ctr Biol Evaluat & Res, Bethesda, MD 20892 USA. NCI, Frederick, MD 21701 USA. Beaucage SL US FDA, Ctr Biol Evaluat & Res, 8800 Rockville Pike, Bethesda, MD 20892 USA.
    1. Year: 2001
  2. Journal: Tetrahedron Letters
    1. 42
    2. 33
    3. Pages: 5635-5639
  4. Type of Article: Article
  1. Abstract:

    An efficient and economical method for the solid-phase synthesis of oligodeoxyribonucleotides and their phosphorothioate analogues is described. The method entails the use of the 4-oxopentyl group for phosphate thiophosphate protection. Post-synthesis removal of the protecting group is easily and rapidly achieved under mild conditions at ambient temperature using either pressurized gaseous amines or concentrated ammonium hydroxide. (C) 2001 Elsevier Science Ltd. All rights reserved.

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