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Microtubules, cell compartments and Rho GTPases: a "menage a trois" for efficient migration

  1. Author:
    Ory, S.
    Jurdic, P.

  2. Author Address

    NCI, FCRF, RCGL, Bldg 560, Rm 22-31, POB B, Frederick, MD 21702 USA. NCI, FCRF, RCGL, Frederick, MD 21702 USA. Ory S NCI, FCRF, RCGL, Bldg 560, Rm 22-31, POB B, Frederick, MD 21702 USA.
    1. Year: 2001
  2. Journal: M S-Medecine Sciences
    1. 17
    2. 8-9
    3. Pages: 878-885
  4. Type of Article: Article
  1. Abstract:

    Dynamic cytoskeleton and membrane plasticity allow higher eucaryotic cells to actively migrate. To move, cells need to correctly integrate both extra and intracellular signals in order to completely reorganize their actin cytoskeleton and corresponding adhesion structures. It is well established that RhoGTPases are pivotal regulators of actin organization making them. key players in the Control of cell migration. Actin organisation between the leading and the rear edges of migrating cells is different, implying the existence of polarized activation and antagonistic activities. of the RhoGTPases within the e cell. Recent data suggest that both microtubules and subcellular compartments influence the local distribution and polarized activity of RhoGTPases in migrating cells.

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