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Live or let die: The cell's response to p53

  1. Author:
    Vousden, K. H.
    Lu, X.

  2. Author Address

    Beatson Inst Canc Res, Garscube Estate,Switchback Rd, Glasgow G61 1BD, Lanark, Scotland NCI, Regulat Cell Growh Lab, Frederick, MD 21702 USA Univ London Imperial Coll Sci Technol & Med, Ludwig Inst Canc Res, Fac Med, London W2 1PG, England Vousden KH Beatson Inst Canc Res, Garscube Estate,Switchback Rd, Glasgow G61 1BD, Lanark, Scotland
    1. Year: 2002
  2. Journal: Nature Reviews Cancer
    1. 2
    2. 8
    3. Pages: 594-604
  4. Type of Article: Review
  1. Abstract:

    Compared with many normal tissues, cancer cells are highly sensitized to apoptotic signals, and survive only because they have acquired lesions - such as loss of p53 - that prevent or impede cell death. We are now beginning to understand the complex mechanisms that regulate whether or not a cell dies in response to p53 - insights that will ultimately contribute to the development of therapeutic strategies to repair the apoptotic p53 response in cancers.

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