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Role of the zinc fingers of HIV-1 nucleocapsid protein in maturation of genomic RNA

  1. Author:
    Baba, S.
    Takahashi, K.
    Koyanagi, Y.
    Yamamoto, N.
    Takaku, H.
    Gorelick, R. J.
    Kawai, G.

  2. Author Address

    Chiba Inst Technol, Fac Engn, Dept Ind Chem, 2-17-1 Tsudanuma, Narashino, Chiba 2750016, Japan Chiba Inst Technol, Fac Engn, Dept Ind Chem, Narashino, Chiba 2750016, Japan Tohoku Univ, Sch Med, Dept Virol, Aoba Ku, Sendai, Miyagi 9808575, Japan Tokyo Med & Dent Univ, Fac Med, Dept Mol Virol, Tokyo 1138519, Japan NCI, SAIC Frederick Inc, dAIDS Vaccine Program, Frederick, MD 21702 USA Kawai G Chiba Inst Technol, Fac Engn, Dept Ind Chem, 2-17-1 Tsudanuma, Narashino, Chiba 2750016, Japan
    1. Year: 2003
  2. Journal: Journal of Biochemistry
    1. 134
    2. 5
    3. Pages: 637-639
  4. Type of Article: Article
  1. Abstract:

    The nucleocapsid protein of HIV-1 consists of two basic amino acid regions and two zinc fingers. We investigated the requirement of these domains for the structural conversion of a 39mer RNA covering the dimerization initiation site by using three peptides; wild-type NCp7, a mutant in which the two zinc fingers are mutated, and another mutant in which the two zinc fingers are deleted. The two mutants exhibited similar conversion activities to each other, which were lower than that of the wildtype, indicating that the two basic regions exhibit some activity for RNA chaperone, as we suggested before, and the zinc fingers enhance the efficiency of this activity

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