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A potent novel anti-HIV protein from the cultured cyanobacterium Scytonema varium

  1. Author:
    Bokesch, H. R.
    O'Keefe, B. R.
    McKee, T. C.
    Pannell, L. K.
    Patterson, G. M. L.
    Gardella, R. S.
    Sowder, R. C.
    Turpin, J.
    Watson, K.
    Buckheit, R. W.
    Boyd, M. R.

  2. Author Address

    Univ S Alabama, Coll Med, USA Canc Res Inst, Mobile, AL 36688 USA Univ S Alabama, Coll Med, USA Canc Res Inst, Mobile, AL 36688 USA So Res Inst, Frederick Res Ctr, Frederick, MD 21701 USA SAIC Frederick, AIDS Vaccine Program, Frederick, MD 21702 USA Univ Hawaii Manoa, Dept Chem, Honolulu, HI 96822 USA NIDDKD, Bioorgan Chem Lab, NIH, Bethesda, MD 20892 USA SAIC Frederick, Basic Res Program, Frederick, MD 21702 USA NCI, Mol Targets Discovery Program, Canc Res Ctr, Frederick, MD USA Boyd MR Univ S Alabama, Coll Med, USA Canc Res Inst, Mobile, AL 36688 USA
    1. Year: 2003
  2. Journal: Biochemistry
    1. 42
    2. 9
    3. Pages: 2578-2584
  4. Type of Article: Article
  1. Abstract:

    A new anti-HIV protein, scytovirin, was isolated from aqueous extracts of the cultured cyanobacterium Scytonema varium. The protein displayed potent anticytopathic activity against laboratory strains and primary isolates of HIV-1 with EC50 values ranging from 0.3 to 22 nM. Scytovirin binds to viral coat proteins gp120, gp160, and gp41 but not to cellular receptor CD4 or other tested proteins. This unique protein consists of a single 95-amino acid chain with significant internal sequence duplication and 10 cysteines forming five intrachain disulfide bonds.

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