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Isolation and Structure of the Human Cancer Cell Growth Inhibitory Cyclodepsipeptide Dolastatin 16

  1. Author:
    Pettit, G. R.
    Xu, J. P.
    Hogan, F.
    Williams, M. D.
    Doubek, D. L.
    Schmidt, J. M.
    Cerny, R. L.
    Boyd, M. R.

  2. Author Address

    Pettit GR ARIZONA STATE UNIV CANC RES INST TEMPE, AZ 85287 USA ARIZONA STATE UNIV DEPT CHEM TEMPE, AZ 85287 USA UNIV NEBRASKA NEBRASKA CTR MASS SPECTROMETRY LINCOLN, NE 68588 USA NCI FREDERICK CANC RES & DEV CTR LAB DRUG DISCOVERY RES & DEV DTP DCTDC FREDERICK, MD 21701 USA
    1. Year: 1997
  2. Journal: Journal of Natural Products
    1. 60
    2. 8
    3. Pages: 752-754
  4. Type of Article: Article
  1. Abstract:

    An investigation of the sea hare Dolabella auricularia from Papua New Guinea has led to discovery of the new cyclodepsipeptide dolastatin 16 (3) containing two new amino acid units designated dolamethylleuine (Dml) and dolaphenvaline (Dpv). The structural elucidation was achieved by means of high-field (500 MHz) NMR and tandem MS/MS mass spectral interpretations and allowed the assignment cyclo-(Pro-Dpv-Pro-Dml-O-Lac-Pro-O-Hiv-MeVal). The new depsipetide exhibited strong inhibition of growth against a variety of human cancer cell lines. [References: 18]

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