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Antineoplastic Agents .362. Isolation and X-Ray Crystal Structure of Dibromophakellstatin From the Indian Ocean Sponge Phakellia Mauritiana

  1. Author:
    Pettit, G. R.
    McNulty, J.
    Herald, D. L.
    Doubek, D. L.
    Chapuis, J. C.
    Schmidt, J. M.
    Tackett, L. P.
    Boyd, M. R.

  2. Author Address

    Pettit GR ARIZONA STATE UNIV DEPT CHEM CANC RES INST TEMPE, AZ 85287 USA NCI LAB DRUG DISCOVERY RES & DEV DTP DCTDC FREDERICK CANC RES & DEV CTR FREDERICK, MD 21702 USA
    1. Year: 1997
  2. Journal: Journal of Natural Products
    1. 60
    2. 2
    3. Pages: 180-183
  4. Type of Article: Article
  1. Abstract:

    Bioassay-guided isolation procedures using human tumor cell lines led to isolation of dibromophakellstatin (4) from the Republic of Seychelles sponge Phakellia mauritiana. The isolation, X-ray crystal structure elucidation, absolute stereochemistry, and antineoplastic activity have been summarized. P. mauritiana was also found to contain dibromophakellin (1), debromohymenialosine (2), thymidine, deoxyuridine, and thymine. [References: 42]

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