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Crystallization and preliminary X-ray studies of thymus and activation-regulated chemokine (TARC)

  1. Author:
    Asojo, O. A.
    Cater, S.
    Hoover, D. M.
    Boulegue, C.
    Lu, W. Y.
    Lubkowski, J.

  2. Author Address

    NCI, Macromol Crystallog Lab, Frederick, MD 21702 USA NCI, Macromol Crystallog Lab, Frederick, MD 21702 USA Univ Maryland Biotechnol Inst, Inst Human Virol, Baltimore, MD 21201 USA Lubkowski J NCI, Macromol Crystallog Lab, Frederick, MD 21702 USA
    1. Year: 2003
  2. Journal: Acta Crystallographica Section D-Biological Crystallography
    1. 59
    2. Part 1
    3. Pages: 163-165
  4. Type of Article: Article
  1. Abstract:

    Thymus and activation-regulated chemokine (TARC) is a CC chemokine that is most highly expressed in the thymus. TARC interacts primarily with the CCR4 receptor and to a lesser extent with the CCR8 receptor. Three different crystal forms of synthetically prepared TARC were grown in triclinic, hexagonal and tetragonal systems. The X-ray data for the triclinic crystals (unit-cell parameters a = 56.46, b = 76.48, c = 88.37 Angstrom, alpha = 85.8, beta = 72.8, gamma = 70.0degrees) extend to 1.85 Angstrom on a conventional radiation source. The hexagonal crystals diffracted to 2.2 Angstrom at a synchrotron- radiation source and belong to either space group P6(1)22 or P6(5)22, with unit-cell parameters a = 61.8, c = 315. Angstrom. The tetragonal crystals diffracted to about 5 Angstrom at a synchrotron-radiation source and had approximate unit-cell parameters a = b = 47.7, c = 58.2 Angstrom.

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