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Reciprocal chromosome painting shows that squirrels, unlike murid rodents, have a highly conserved genome organization

  1. Author:
    Stanyon, R.
    Stone, G.
    Garcia, M.
    Froenicke, L.

  2. Author Address

    NCI, Comparat Mol Cytogenet Core, Genet Branch, Bldg 560,Room 11-74A, Frederick, MD 21702 USA NCI, Comparat Mol Cytogenet Core, Genet Branch, Frederick, MD 21702 USA Univ Autonoma Barcelona, Dept Biol Cellular Fisiol & Immunol, E-08193 Barcelona, Spain Stanyon R NCI, Comparat Mol Cytogenet Core, Genet Branch, Bldg 560,Room 11-74A, Frederick, MD 21702 USA
    1. Year: 2003
  2. Journal: Genomics
    1. 82
    2. 2
    3. Pages: 245-249
  4. Type of Article: Article
  1. Abstract:

    We present the first report of reciprocal chromosome painting between humans and a rodent. Gene mapping and sequencing data lead to the generalization that rodent genomes are highly rearranged. In contrast, our results show a surprising conservation of genome structure between humans and squirrels. The synteny of 12 human chromosomes was entirely conserved (5, 6, 9, 11, 13-15, 17, 18, 20, 21, and X). Of the 12 syntenic associations of human chromosomes present in the squirrel, six are well-known ancestral eutherian associations (3/21, 4/8, 7/16, 12/22, 14/15, 16/19). Apparently, few derived translocations characterize the evolutionary origin of the rodents. One association (10p/1qter) may be a cladistic marker for the cohort Glires, linking rodents and lagomorphs. (C) 2003 Elsevier Science (USA). All rights reserved.

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