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Modifications of histone cores and tails in V(D)J recombination

  1. Author:
    Muegge, K.

  2. Author Address

    NCI, Mol Immunoregulat Lab, SAIC Basic Sci Program, Frederick, MD 21701 USA NCI, Mol Immunoregulat Lab, SAIC Basic Sci Program, Frederick, MD 21701 USA Muegge K NCI, Mol Immunoregulat Lab, SAIC Basic Sci Program, Frederick, MD 21701 USA
    1. Year: 2003
  2. Journal: Genome Biology
    1. 4
    2. 4
    3. Pages: art. no.-211
  4. Type of Article: Review
  1. Abstract:

    The organization of chromatin and modifications to the tails of histone proteins are thought to be important in regulating the rearrangement of V, D and J gene segments, which encode immunoglobulins and T-cell receptors. A recent study shows that methylated lysine 79 in the core region of histone H3 also plays a role by providing a euchromatic 'mark' that may regulate access of the V( D) J recombinase.

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