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Molecular mechanisms of filovirus cellular trafficking

  1. Author:
    Aman, M. J.
    Bosio, C. M.
    Panchal, R. G.
    Burnett, J. C.
    Schmaljohn, A.
    Bavari, S.

  2. Author Address

    Clin Res Management Inc, 1425 Porter St, Frederick, MD 21702 USA Clin Res Management Inc, Frederick, MD 21702 USA USA, Med Res Inst Infect Dis, Dept Cell Biol & Biochem, USAMRIID, Frederick, MD 21702 USA NCI, SAIC, Target Struct Based Drug Discovery Grp, Dev Therapeut Program, Frederick, MD 21702 USA Aman MJ Clin Res Management Inc, 1425 Porter St, Frederick, MD 21702 USA
    1. Year: 2003
  2. Journal: Microbes and Infection
    1. 5
    2. 7
    3. Pages: 639-649
  4. Type of Article: Review
  1. Abstract:

    The filoviruses, Ebola and Marburg, are two of the most pathogenic viruses, causing lethal hemorrhagic fever in humans. Recent discoveries suggest that filoviruses, along with other phylogenetically or functionally related viruses, utilize a complex mechanism of replication exploiting multiple cellular components including lipid rafts, endocytic compartments, and vacuolar protein sorting machinery. In this review, we summarize these recent findings and discuss the implications for vaccine and therapeutics development. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

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