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Assay for ubiquitin ligase activity: High-throughput screen for inhibitors of HDM2

  1. Author:
    Davydov, I. V.
    Woods, D.
    Safiran, Y. J.
    Oberoi, P.
    Fearnhead, H. O.
    Fang, S.
    Jensen, J. P.
    Weissman, A. M.
    Kenten, J. H.
    Vousden, K. H.

  2. Author Address

    Meso Scale Diagnost LLC, Meso Scale Discovery, Gaithersburg, MD USA. NCI, Regulat Cell Growth Lab, Canc Res Ctr, Frederick, MD 21701 USA. NCI, Lab Prot Dynam & Signaling, Ctr Canc Res, Frederick, MD 21701 USA Vousden, KH, Beatson Inst Canc Res, Garscube Estate,Switchback Rd, Glasgow G61 1BD, Lanark, Scotland
    1. Year: 2004
    2. Date: DEC
  2. Journal: Journal of Biomolecular Screening
    1. 9
    2. 8
    3. Pages: 695-703
  4. Type of Article: Article
  1. Abstract:

    An assay for the autoubiquitination activity of the E3 ligase HDM2 (Mdm2) was developed and adapted to a high-throughput formal to identify inhibitors of this activity. The assay can also be used to measure the activity of other E3s and may be useful in finding both inhibitors and activators of a wide range of different ubiquitin ligases

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External Sources

  1. View record in Web of Science®
  2. WOS: 000225914100005

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