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Cytotoxic alkaloids from the marine sponge Thorectandra sp

  1. Author:
    Charan, R. D.
    McKee, T. C.
    Boyd, M. R.

  2. Author Address

    Mckee, TC, NCI, Mol Targets Dev Program, Ctr Canc Res, Frederick, MD 21702 USA NCI, Mol Targets Dev Program, Ctr Canc Res, Frederick, MD 21702 USA.
    1. Year: 2004
  2. Journal: Natural Product Research
    1. 18
    2. 3
    3. Pages: 225-229
  4. Type of Article: Article
  1. Abstract:

    Three beta-carboline alkaloids, Compound 1, 1-deoxysecofascaplysin A ( 2), and fascaplysin ( 3), were isolated from the aqueous and organic extracts of the marine sponge Thorectandra sp. The structures of 1 and 2 were determined on the basis of spectral data. Compound 1 inhibited the growth of MCF-7 ( breast) with an IC50 of 5.9 mug/mL while Compound 2 inhibited the growth of MCF-7 as well as OVCAR-3 ( ovarian) human tumor cell lines with IC(50)s of 1.5 and 2.2 mug/mL, respectively

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External Sources

  1. View record in Web of Science®
  2. WOS: 000221242000006

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