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Coupling morphogenesis to mitotic entry

  1. Author:
    Sakchaisri, K.
    Asano, S.
    Yu, L. R.
    Shulewitz, M. J.
    Park, C. J.
    Park, J. E.
    Cho, Y. W.
    Veenstra, T. D.
    Thorner, J.
    Lee, K. S.

  2. Author Address

    Lee, KS, NCI, Ctr Canc Res, Lab Metab, NIH, 9000 Rockville Pike,Bldg 37,Room 3118, Bethesda, MD 20892 USA NCI, Ctr Canc Res, Lab Metab, NIH, Bethesda, MD 20892 USA. NCI, Mass Spectrometry Ctr, Ft Detrick, MD 21702 USA. Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA. Mahidol Univ, Fac Sci, Dept Pharmacol, Bangkok 10400, Thailand.
    1. Year: 2004
  2. Journal: Proceedings of the National Academy of Sciences of the United States of America
    1. 101
    2. 12
    3. Pages: 4124-4129
  4. Type of Article: Article
  1. Abstract:

    In eukaryotes, cyclin B-bound cyclin-dependent protein kinase 1 promotes mitotic entry but is held in check, in part, by Wee1 protein kinase. Timely mitotic entry in budding yeast requires inactivation of Swell (Wee1 ortholog). Perturbations of the septin collar at the bud neck lead to Swe1 stabilization, delaying the G(2)/M transition. Swell is recruited to the neck and hyperphosphorylated before ubiquitin-mediated degradation. Hsl1 kinase (Nim1 ortholog), a negative regulator of Wee1, is required for efficient Swell localization at the neck but seems not to phosphorylate Swe1. Here, we show that two other kinases targeted sequentially to the neck, Cla4/PAK and Cdc5/Polo, are responsible for stepwise phosphorylation and down-regulation of Swell. This mechanism links assembly of a cellular structure to passage into mitosis

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