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Neamphamide A, a new HIV-Inhibitory depsipeptide from the Papua New Guinea marine sponge Neamphius huxleyi

  1. Author:
    Oku, N.
    Gustafson, K. R.
    Cartner, L. K.
    Wilson, J. A.
    Shigematsu, N.
    Hess, S.
    Pannell, L. K.
    Boyd, M. R.
    McMahon, J. B.

  2. Author Address

    NCI, Mol Targets Dev Program, Ctr Canc Res, Frederick, MD 21702 USA. SAIC Frederick, Intramural Res Support Program, Frederick, MD 21702 USA. NIDDKD, Bioorgan Chem Lab, Bethesda, MD 20892 USA. Univ S Alabama, Coll Med, USA Canc Res Inst, Mobile, AL 36688 USA Gustafson, KR, NCI, Mol Targets Dev Program, Ctr Canc Res, Bldg 1052,Room 121, Frederick, MD 21702 USA
    1. Year: 2004
    2. Date: AUG
  2. Journal: Journal of Natural Products
    1. 67
    2. 8
    3. Pages: 1407-1411
  4. Type of Article: Article
  1. Abstract:

    A new HIV-inhibitory cyclic depsipeptide, neamphamide A (2), was isolated from a Papua New Guinea collection of the marine sponge Neamphius huxleyi. Its structure was established through interpretation of spectroscopic data and by acid hydrolysis, derivatization of the free amino acids, and LC-MS analysis of the derivatives. Neamphamide A (2) contains 11 amino acid residues and an amide-linked 3-hydroxy-2,4,6-trimethylheptanoic acid moiety. The amino acid constituents were identified as L-Leu, L-NMeGln, D-Arg, D- and L-Asn, two residues of D-allo-Thr, L-homoproline, (3S,4R)-3,4-dimethyl-L-glutamine, beta-methoxytyrosine, and 4-amino-7-guanidino-2,3-dihydroxyheptanoic acid. In a cell-based XTT assay, 2 exhibited potent cytoprotective activity against HIV-1 infection with an EC50 of approximately 28 nM

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External Sources

  1. View record in Web of Science®
  2. WOS: 000223600200036

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