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Sequence analysis of a 700kb DNA segment in 3p21.3 containing the putative small cell lung cancer gene: A window into a gene rich region of the human genome

  1. Author:
    Wei, M. H.
    Latif, F.
    Duh, F. M.
    Sekido, Y.
    Bader, S.
    Chen, J. Y.
    Kuzmin, I.
    Geil, L.
    Kashuba, V.
    Zabarovsky, E.
    Klein, G.
    Zbar, B.
    Minna, J.
    Lerman, M.
    1. Year of Conference: 1997
  2. Conference Name: Annual Meeting of the American Association for Cancer Research
    1. 38
    2. Pages: A472
  4. Type of Work: Meeting Abstract
  1. Abstract:

    Previously we and others identified and defined by overlapping homozygous deletions a small region on chromosome 3p located in 3p21.3 to contain a tumor suppressor gene that cause all major forms of lung cancer and is likely involved in the genesis of breast, cervical, and head and neck carcinomas. The region was covered by a 700 kb clone contig and further narrowed to 370 kb by positioning the breakpoints of the overlapping deletions on a restriction map of the contig (Wei et al, Cancer Research; 56:1487-92 1996). The entire 700 kb segment is now being sequenced jointly by The Genome Sequence Center at WU, St.Louis and The Sanger Centre, Hinxton, UK. We will present a comprehensive analysis of the 700 kb sequence by superimposing on the covalent map the position and the genomic structure of genes, repetitive elements, microsatellites, the ESTs, and CpG islands. The genomic organization of this highly dense gene region provides a unique example of a 'small window into the human genome'.

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