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Application of Mixed Mobile Phases and a Step Gradient Method in Capillary Electrochromatography For the Separation of Isomeric Polycyclic Aromatic Hydrocarbon-Deoxyribonucleoside Adduct Mixtures Prepared in Vitro

  1. Author:
    Ding, J. M.
    Szeliga, J.
    Dipple, A.
    Vouros, P.

  2. Author Address

    Vouros P NORTHEASTERN UNIV DEPT CHEM BOSTON, MA 02115 USA NORTHEASTERN UNIV DEPT CHEM BOSTON, MA 02115 USA NORTHEASTERN UNIV BARNETT INST BOSTON, MA 02115 USA NCI FREDERICK CANC RES & DEV CTR ABL BASIC RES PROGRAM FREDERICK, MD 21702 USA
    1. Year: 1997
  2. Journal: Journal of Chromatography
    1. 781
    2. 1-2
    3. Pages: 327-334
  4. Type of Article: Article
  1. Abstract:

    Capillary electrochromatography (CEC) was used for the analysis of mixtures of neutral isomeric compounds derived from the reaction of carcinogenic hydrocarbon (benzo[g]chrysene and 5,6-dimethylchrysene) dihydrodiol epoxides with calf thymus deoxyribonucleic acid (DNA). The CEC analysis demonstrated higher resolution, greater speed and lower analyte consumption than high-performance liquid chromatography (HPLC) in the analysis of the same samples using the same type of stationary phase. Proper selection of the mixed mobile phases was critical for the separation of these complex mixtures with enhanced speed and selectivity. The use of a step gradient further improved the speed of the CEC analysis resulting in electrochromatograms that required only 25-70% of the corresponding HPLC analysis times. (C) 1997 Elsevier Science B.V. [References: 27]

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