Skip NavigationSkip to Content
Return Return to Search Results

Resveratrol inhibits nitric oxide and TNF-alpha production by lipopolysaccharide-activated microglia

  1. Author:
    Bi, X. L.
    Yang, J. Y.
    Dong, Y. X.
    Wang, J. M.
    Cui, Y. H.
    Ikeshima, T.
    Zhao, Y. Q.
    Wu, C. F.

  2. Author Address

    Shenyang Pharmaceut Univ, Dept Pharmacol, Shenyang 110016, Peoples R China. SAIC Frederick, Mol Immunoregulat Lab, Canc Res Ctr, Natl Canc Inst, Frederick, MD USA. Lanzhou Mil Med Univ, Biochem Sect, Lanzhou, Peoples R China. Shenyang Pharmaceut Univ, Sino Japan Inst Med, Shenyang 110016, Peoples R China Wu, CF, Shenyang Pharmaceut Univ, Dept Pharmacol, Shenyang 110016, Peoples R China
    1. Year: 2005
    2. Date: JAN
  2. Journal: International Immunopharmacology
    1. 5
    2. 1
    3. Pages: 185-193
  4. Type of Article: Article
  1. Abstract:

    Upon activation, brain macrophages, the microglia, release proinflammatory mediators that play important roles in eliciting neuroinflammatory responses associated with neurodegenerative diseases. As resveratrol, an antioxidant component of grape, has been reported to exert anti-inflammatory activities on macrophages, we investigated its effects on the production of TNF-alpha (TNF-alpha) and nitric oxide (NO) by lipopolysaccharide (LPS)-activated microglia. Exposure of cultured rat cortical microglia and a mouse microglial cell line N9 to LPS increased their release of TNF-alpha and NO, which was significantly inhibited by resveratrol. Further studies revealed that resveratrol suppressed LPS-induced degradation of IkappaBalpha, expression of NOS and phosphorylation of p38 mitogen-activated protein kinases (MAPKs) in N9 microglial cells. These results demonstrate a potent suppressive effect of resveratrol on proinflammatory responses of microglia, suggesting a therapeutic potential for this compound in neurodegenerative diseases accompanied by microglial activation. (C) 2004 Elsevier B.V. All rights reserved

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1016/j.intimp.2004.08.008
  3. View record in Web of Science®
  4. WOS: 000226615400028

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel