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In vitro selective suppression of feline myeloid colony formation is attributable to molecularly cloned strain of feline leukemia virus with unique long terminal repeat

  1. Author:
    Nagashima, N.
    Hisasue, M.
    Nishigaki, K.
    Miyazawa, T.
    Kano, R.
    Hasegawa, A.

  2. Author Address

    Azabu Univ, Sch Vet Med, Lab Vet Internal Med 2, Sagamihara, Kanagawa 2298501, Japan. Nihon Univ, Sch Vet Med, Dept Pathobiol, Fujisawa, Kanagawa 2528510, Japan. NCI, Basic Res Lab, Frederick, MD 21702 USA. Japan Sci & Technol Agcy, PRESTO, Host & Def, Kawaguchi, Saitama 3320012, Japan. Obihiro Univ Agr & Vet Med, Dept Vet Publ Hlth, Obihiro, Hokkaido 0808555, Japan Hisasue, M, Azabu Univ, Sch Vet Med, Lab Vet Internal Med 2, 1-17-71,Fuchinobe, Sagamihara, Kanagawa 2298501, Japan
    1. Year: 2005
    2. Date: APR
  2. Journal: Research in Veterinary Science
    1. 78
    2. 2
    3. Pages: 151-154
  4. Type of Article: Article
  1. Abstract:

    Molecularly cloned feline leukemia virus (FeLV)-clone 33 (C-33), derived from a cat with acute myelocytic leukemia (AML), was examined to assess its relation to the pathogenesis of AML and myelodysplastic syndrome (MDS). To evaluate in vitro pathogenicity of FeLV C-33, bone marrow colony-forming assay was performed on marrow cells infected with FeLV C-33 or an FeLV subgroup A strain (61E, a molecularly cloned strain with minimal pathogenicity). The myeloid colony-forming activity of feline bone marrow mononuclear cells infected with FeLV C-33 was significantly lower than that of cells infected with 61E. This suggests that FeLV C-33 has myeloid lineage-specific pathogenicity for cats, and that FeLV C-33 infection is useful as an experimental model for investigating pathogenesis of MDS and AML. (C) 2004 Elsevier Ltd. All rights reserved

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  2. WOS: 000227005500008

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