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A rhesus macaque radiation hybrid map and comparative analysis with the human genome

  1. Author:
    Murphy, W. J.
    Agarwala, R.
    Schaffer, A. A.
    Stephens, R.
    Smith, C.
    Crumpler, N. J.
    David, V. A.
    O'Brien, S. J.

  2. Author Address

    NCI, Basic Res Lab, SAIC Frederick Inc, Lab Genom Divers, Frederick, MD 21702 USA. NIH, Natl Lib Med, NCBI, IEB,Dept Hlth & Human Serv, Bethesda, MD 20894 USA. NIH, Natl Lib Med, NCBI, CBB,Dept Hlth & Human Serv, Bethesda, MD 20894 USA. NCI, Adv Biomed Comp Ctr, Frederick, MD 21702 USA Murphy, WJ, Texas A&M Univ, Coll Vet Med & Biomed Sci, Dept Vet Integrat Biosci, Mail Stop 4458, College Stn, TX 77843 USA
    1. Year: 2005
    2. Date: OCT
  2. Journal: Genomics
    1. 86
    2. 4
    3. Pages: 383-395
  4. Type of Article: Article
  1. Abstract:

    The genomes of nonhuman primates are powerful references for better understanding the recent evolution of the human genome. Here we compare the order of 802 genomic markers mapped in a rhesus macaque (Macaca mulatta) radiation hybrid panel with the human genome, allowing for nearly complete cross-reference to the human genome at an average resolution of 3.5 Mb. At least 23 large-scale chromosomal rearrangements, mostly inversions, are needed to explain the changes in marker order between human and macaque. Analysis of the breakpoints flanking inverted chromosomal segments and estimation of their duplication divergence dates provide additional evidence implicating segmental duplications as a major mechanism of chromosomal rearrangement in recent primate evolution. Published by Elsevier Inc

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External Sources

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  2. DOI: 10.1016/j.ygeno.2005.05.013
  3. View record in Web of Science®
  4. WOS: 000232122400001

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