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Epstein-Barr virus-encoded latent membrane protein 1 modulates cyclin D1 by c-Jun/Jun B heterodimers

  1. Author:
    Song, X.
    Tao, Y. G.
    Zeng, L.
    Yang, J.
    Tang, F. Q.
    Lee, L. M.
    Gong, J. P.
    Wu, Q.
    Cao, Y.

  2. Author Address

    Cent S Univ, Canc Res Inst, Xiangya Sch Med, Changsha 410078, Peoples R China. NCI, Lab Mol Technol, SAIC Frederick, Frederick, MD 21702 USA. Tongji Med Univ, Mol Med Ctr, Tongji Hosp, Wuhan 430030, Peoples R China. Xiamen Univ, Key Lab Cell Biol & Tumor Cell Engn, Minist Educ, Sch Life Sci, Xiamen 361005, Peoples R China Cao, Y, Cent S Univ, Canc Res Inst, Xiangya Sch Med, Changsha 410078, Peoples R China
    1. Year: 2005
    2. Date: AUG
  2. Journal: Science in China Series C-Life Sciences
    1. 48
    2. 4
    3. Pages: 385-393
  4. Type of Article: Article
  1. Abstract:

    In our recent studies, we found that LMP1 encoded by Epstein-Barr virus could accelerate the formation of active c-Jun/Jun B heterodimer. We studied the regulation of cyclinD1 by c-Jun/Jun B heterodimers by laser scanning confocal influorescence microscopy, Western blot, luciferase activity assay, super-EMSA and flow cytometry in the Tet-on-LMP1 HNE2 cell line, in which LMP1 expression was regulated by Tet-on system. c-Jun/Jun B heterodimers induced by LMP1 could up regulate cyclin D1 promoter activity and expression. Overexpression of cyclin-D1 accelerated the progression of cell cycle

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External Sources

  1. View record in Web of Science®
  2. WOS: 000232174800009

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