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Zebularine: A unique molecule for an epigenetically based strategy in cancer chemotherapy. The magic of its chemistry and biology

  1. Author:
    Marquez, V. E.
    Barchi, J. J.
    Kelley, J. A.
    Rao, K. V. R.
    Agbaria, R.
    Ben-Kasus, T.
    Cheng, J. C.
    Yoo, C. B.
    Jones, P. A.

  2. Author Address

    NCI, Ctr Canc Res, Med Chem Lab, NIH, Frederick, MD 21702 USA. Ben Gurion Univ Negev, Dept Clin Pharmacol, Fac Hlth Sci, IL-84105 Beer Sheva, Israel. Univ So Calif, Keck Sch Med, Norris Comprehens Canc Ctr, Dept Urol, Los Angeles, CA USA. Univ So Calif, Keck Sch Med, Norris Comprehens Canc Ctr, Dept Biochem & Mol Biol, Los Angeles, CA USA Marquez, VE, NCI, Ctr Canc Res, Med Chem Lab, NIH, Frederick, MD 21702 USA
    1. Year: 2005
  2. Journal: Nucleosides Nucleotides & Nucleic Acids
    1. 24
    2. 5-7, Sp. Iss.
    3. Pages: 305-318
  4. Type of Article: Article
  1. Abstract:

    1-(beta-(D)-ribofuranosyl)- 1,2-dihydropyrimidin-2-one (zebularine) is structurally 4-deamino cytidine. The increased electraphilic character of this simple aglycon endows the molecule with unique chemical and biological properties, making zebularine a versatile starting material for the synthesis of complex nucleosides and an effective inhibitor of cytidine deaminase and DNA cytosine methyltransferase. Zebularine is a stable, antitumor agent that preferentially targets cancer cells and shows activity both in vitro and in experimental animals, even after oral administration

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External Sources

  1. View record in Web of Science®
  2. WOS: 000232473500001

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