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Enhanced cellular immunity to SIV Gag following co-administration of adenoviruses encoding wild-type or mutant HIV Tat and SIV Gag

  1. Author:
    Zhao, J.
    Voltan, R.
    Peng, B.
    vis-Warren, A.
    Kalyanaraman, V. S.
    Alvord, W. G.
    Aldrich, K.
    Bernasconi, D.
    Butto, S.
    Cafaro, A.
    Ensoli, B.
    Robert-Guroff, M.

  2. Author Address

    NCI, Bethesda, MD 20892 USA. Adv Biosci Labs Inc, Kensington, MD 20895 USA. NCI, Data Management Serv, Frederick, MD 21702 USA. Ist Super Sanita, AIDS Div, Dept Infect Parasit & Immunomediated Dis, I-00161 Rome, Italy Robert-Guroff, M, NCI, 41 Medlars Dr,Bldg 41,Room D804, Bethesda, MD 20892 USA
    1. Year: 2005
    2. Date: NOV 10
  2. Journal: Virology
    1. 342
    2. 1
    3. Pages: 1-12
  4. Type of Article: Article
  1. Abstract:

    Among candidate antigens for human immunodeficiency virus (HIV) prophylactic vaccines, the regulatory protein Tat is a critical early target, but has a potential for immune suppression. Adenovirus (Ad) recombinants encoding wild-type HIV Tat (Tat-wt) and a transdominant negative mutant HIV Tat (Tat22) were constructed and administered to mice separately or together with Ad-SIVgag. Immumogenicity and effects on immune responses to the co-administered Gag immunogen were evaluated. Wild-type and mutant Tat recombinants elicited similar Tat-specific cellular and humoral immune responses. Co-administration of either Tat immunogen with Ad-SIVgag induced modest but significant enhancement of Gag-specific interferon-gamma secreting T cells and lymphoproliferative responses. Neither the Ad-recombinant encoding Tat-wt nor Tat22 suppressed induction of anti-Tat or anti-Gag antibodies. Based on the immune responses observed in mice, both recombinants appear to be suitable vaccine candidates. Their contribution to protective efficacy remains to be determined in a non-human primate model. Published by Elsevier Inc

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  2. DOI: 10.1016/j.virol.2005.07.016
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