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AIDS restriction HLA allotypes target distinct intervals of HIV-1 pathogenesis

  1. Author:
    Gao, X. J.
    Bashirova, A.
    Iversen, A. K. N.
    Phair, J.
    Goedert, J. J.
    Buchbinder, S.
    Hoots, K.
    Vlahov, D.
    Altfeld, M.
    O'Brien, S. J.
    Carrington, M.

  2. Author Address

    NCI, Lab Genom Divers, SAIC Frederick, Basic Res Program, Frederick, MD 21702 USA. Johns Hopkins Univ, Sch Med, Baltimore, MD 21231 USA. Univ Oxford, John Radcliffe Hosp, Weatherall Inst Mol Med, MRC Human Immunol Unit, Oxford OX3 9DS, England. Northwestern Univ, Howard Brown Hlth Ctr, Chicago, IL 60611 USA. Northwestern Univ, Fineberg Sch Med, Chicago, IL 60611 USA. NCI, Viral Epidemiol Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA. San Francisco Dept Publ Hlth, San Francisco, CA 94102 USA. Univ Texas, Hlth Sci Ctr, Gulf States Hemophilia Ctr, Houston, TX 77030 USA. New York Acad Med, Ctr Urban Epidemiol Studies, New York, NY 10029 USA. Massachusetts Gen Hosp, Partners AIDS Res Ctr, Charlestown, MA 02129 USA. NCI, Lab Genom Divers, Frederick, MD 21702 USA Carrington, M, NCI, Lab Genom Divers, SAIC Frederick, Basic Res Program, POB B, Frederick, MD 21702 USA
    1. Year: 2005
    2. Date: DEC
  2. Journal: Nature Medicine
    1. 11
    2. 12
    3. Pages: 1290-1292
  4. Type of Article: Article
  1. Abstract:

    An effective acquired immune response to infectious agents mediated by HLA-restricted T-cell recognition can target different stages of disease pathogenesis. We show here that three distinct HLA alleles known to alter the overall rate of AIDS progression act during distinct intervals after HIV-1 infection. The discrete timing of HLA allele influence suggests alternative functional mechanisms in immune defense against this dynamic and chronic immunosuppressive disease

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External Sources

  1. View record in Web of Science®
  2. WOS: 000233774400025

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