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The level of reverse transcriptase (RT) in human immunodeficiency virus type 1 particles affects susceptibility to nonnucleoside RT inhibitors but not to lamivudine

  1. Author:
    Ambrose, Z.
    Julias, J. G.
    Boyer, P. L.
    KewalRamani, V. N.
    Hughes, S. H.

  2. Author Address

    NCI, Frederick, MD 21702 USA. SAIC Frederick, HIV Drug Resistance Program, Frederick, MD 21702 USA. SAIC Frederick, Basic Res Program, Frederick, MD 21702 USA.;Hughes, SH, NCI, Bldg 539,Room 130A, Frederick, MD 21702 USA.;hughes@ncifcrf.gov
    1. Year: 2006
    2. Date: Mar
  2. Journal: Journal of Virology
    1. 80
    2. 5
    3. Pages: 2578-2581
  4. Type of Article: Article
  5. ISSN: 0022-538X
  1. Abstract:

    We investigated the relationship between the level of reverse transcriptase (RT) in human immunodeficiency virus type 1 (HIV-1) particles and susceptibility to normucleoside reverse transcriptase inhibitors (NNRTIs). HIV-1 virions containing different active levels of RT were generated. Susceptibility to the NNRT1s efavirenz and nevirapine was inversely proportional to the level of enzymatically active RT. However, the sensitivity of HIV-1 to the nucleoside analog 3TC was not affected by the level of RT per particle. These data indicate that the susceptibility of HIV-1 to NNRT1s is influenced by RT activity.

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External Sources

  1. View Full Text
  2. DOI: 10.1128/jvi.80.5.2578-2581.2006
  3. View record in Web of Science®
  4. WOS: 000235388400050

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