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Long lasting control and lack of pathogenicity of the attenuated Rev-independent SIV in rhesus macaques

  1. Author:
    von Gegerfelt, A. S.
    Alicea, C.
    Valentin, A.
    Morrow, M.
    van Rompay, K. K. A.
    Ayash-Rashkovsky, M.
    Markham, P.
    Else, J. G.
    Marthas, M. L.
    Pavlakis, G. N.
    Ruprecht, R. M.
    Felber, B. K.

  2. Author Address

    Natl Canc Inst, Canc Res Ctr, Human Retrovirus Pathogenesis Sect, Vaccine Branch, Frederick, MD 21702 USA. NCI, Human Retrovirus Sect, Vaccine Branch, Ctr Canc Res, Frederick, MD 21702 USA. Calif Natl Primate Res Ctr, Davis, CA 95616 USA. Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA. Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA. Adv BioSci Labs Inc, Kensington, MD 20895 USA. Emory Univ, Yerkes Natl Primate Res Ctr, Atlanta, GA 30322 USA.;Felber, BK, Natl Canc Inst, Canc Res Ctr, Human Retrovirus Pathogenesis Sect, Vaccine Branch, Bldg 535,Room 209, Frederick, MD 21702 USA.;felber@ncifcrf.gov
    1. Year: 2006
    2. Date: Jun
  2. Journal: Aids Research and Human Retroviruses
    1. 22
    2. 6
    3. Pages: 516-528
  4. Type of Article: Article
  5. ISSN: 0889-2229
  1. Abstract:

    A cohort of 22 rhesus macaques of Indian origin infected as neonates, juveniles, or adults by Rev-independent strains of SIV was monitored over several years. After the initial acute phase, virus replication was controlled and plasma virus loads were persistently below the threshold of the assay. The animals were monitored for up to 7.6 years after infection for viral loads, cellular and humoral immune responses, hematological changes, and overall health and no signs of immune dysfunction or AIDS were observed. This study represents several years of additional observation compared to the previously published results, and indicates that the Rev-independent SIV clones tested do not cause AIDS-like progressive disease within 7.6 years from infection. All the animals showed persistent humoral and cellular SIV-specific immune responses, consistent with chronic infection. Different Rev-independent SIV strains showed similar properties and lack of pathogenicity. Multicolor flow cytometric analysis demonstrated preservation of the Central Memory subset of T cells in the attenuated SIV-infected animals. This study demonstrates a potent, long-lasting control of the Rev-independent attenuated SIV in macaques independent of the age at virus exposure.

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External Sources

  1. View record in Web of Science®
  2. WOS: 000238789300007

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