Skip NavigationSkip to Content
Return Return to Search Results

Interleukin-15 but not interleukin-7 abrogates vaccine-induced decrease in virus level in simian immunodeficiency virus(mac251)-infected macaques

  1. Author:
    Hryniewicz, A.
    Price, D. A.
    Moniuszko, M.
    Boasso, A.
    Edghill-Spano, Y.
    West, S. M.
    Venzon, D.
    Vaccari, M.
    Tsai, W. P.
    Tryniszewska, E.
    Nacsa, J.
    Villinger, F.
    Ansari, A. A.
    Trindade, C. J.
    Morre, M.
    Brooks, D.
    Arlen, P.
    Brown, H. J.
    Kitchen, C. M. R.
    Zack, J. A.
    Douek, D. C.
    Shearer, G. M.
    Lewis, M. G.
    Koup, R. A.
    Franchini, G.

  2. Author Address

    NCI, Anim Models & Retroviral Sect, Bldg 41,Room D804, Bethesda, MD 20892 USA. Med Univ Bialystok, Bialystok, Poland. NIAID, Vaccine Res Ctr, Human Immunol Sect, Bethesda, MD 20892 USA. NCI, Expt Immunol Branch, Bethesda, MD 20892 USA. NIAID, Immunol Lab, Vaccine Res Ctr, Bethesda, MD 20892 USA. NCI, Biostat & Data Management Sect, Bethesda, MD 20892 USA. Emory Univ, Dept Pathol & Lab Med, Sch Med, Atlanta, GA 30322 USA. Cytheris, Issy Les Moulineaux, France. Univ Calif Los Angeles, David Geffen Med Sch, Los Angeles, CA 90095 USA. Bioqual, Rockville, MD 20850 USA. So Res Inst, Frederick, MD 21701 USA. Univ Calif Los Angeles, Sch Publ Hlth, Dept Biostat, Los Angeles, CA 90095 USA.;Franchini, G, NCI, Anim Models & Retroviral Sect, Bldg 41,Room D804, Bethesda, MD 20892 USA.;franchig@mail.nih.gov
    1. Year: 2007
    2. Date: Mar
  2. Journal: Journal of Immunology
    1. 178
    2. 6
    3. Pages: 3492-3504
  4. Type of Article: Article
  5. ISSN: 0022-1767
  1. Abstract:

    The loss of CD4(+) T cells and the impairment of CD8(+) T cell function in HIV infection suggest that pharmacological treatment with IL-7 and IL-15, cytokines that increase the homeostatic proliferation of T cells and improve effector function, may be beneficial. However, these cytokines could also have a detrimental effect in HIV-1-infected individuals, because both cytokines increase HIV replication in vitro. We assessed the impact of IL-7 and IL-15 treatment on viral replication and the immunogenicity of live poxvirus vaccines in SIVmac251-infected macaques (Macaca mulatta). Neither cytokine augmented the frequency of vaccine-expanded CD4(+) or CD8(+) memory T cells, clonal recruitment to the SIV-specific CD8(+) T cell pool, or CD8(+) T cell function. Vaccination alone transiently decreased the viral set point following antiretroviral therapy suspension. IL-15 induced massive proliferation of CD4(+) effector T cells and abrogated the ability of vaccination to decrease set point viremia. In contrast, IL-7 neither augmented nor decreased the vaccine effect and was associated with a decrease in TGF-beta expression. These results underscore the importance of testing immunomodulatory approaches in vivo to assess potential risks and benefits for HIV-1-infected individuals.

    See More

  1. Keywords:

External Sources

  1. View record in Web of Science®
  2. WOS: 000244942400019

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel