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pygopus 2 has a crucial, Wnt pathway-independent function in lens induction

  1. Author:
    Song, N.
    Schwab, K. R.
    Patterson, L. T.
    Yamaguchi, T.
    Lin, X. H.
    Potter, S. S.
    Lang, R. A.

  2. Author Address

    Childrens Hosp Res Fdn, Div Pediat Ophthalmol, Cincinnati, OH 45229 USA. Childrens Hosp Res Fdn, Div Dev Biol, Cincinnati, OH 45229 USA. Univ Cincinnati, Dept Ophthalmol, Cincinnati, OH 45229 USA. Univ Cincinnati, Coll Med, Grad Program Mol & Dev Biol, Cincinnati, OH 45229 USA. Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA. Childrens Hosp Res Fdn, Div Nephrol, Cincinnati, OH 45229 USA. NCI, Cell Signaling Vertebrate Dev Sect, Canc & Dev Biol Lab, Frederick, MD 21701 USA.;Lang, RA, Childrens Hosp Res Fdn, Div Pediat Ophthalmol, Cincinnati, OH 45229 USA.;Richard.Lang@cchmc.org
    1. Year: 2007
    2. Date: May
  2. Journal: Development
    1. 134
    2. 10
    3. Pages: 1873-1885
  4. Type of Article: Article
  5. ISSN: 0950-1991
  1. Abstract:

    Drosophila Pygopus was originally identified as a core component of the canonical Wnt signaling pathway and a transcriptional coactivator. Here we have investigated the microophthalmia that arises in mice with a germline null mutation of pygopus 2. We show that this phenotype is a consequence of defective lens development at inductive stages. Using a series of regionally limited Cre recombinase transgenes for conditional deletion of Pygo2(flox), we show that Pygo2 activity in pre-placodal presumptive lens ectoderm, placodal ectoderm and ocular mesenchyme all contribute to lens development. In each case, Pygo2 is required for normal expression levels of the crucial transcription factor Pax6. Finally, we provide multiple lines of evidence that although Pygo2 can function in the Wnt pathway, its activity in lens development is Wnt pathway-independent.

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External Sources

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  2. DOI: 10.1242/dev.001495
  3. View record in Web of Science®
  4. WOS: 000246138700007

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