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A dimeric lactone from Ardisia japonica with inhibitory activity for HIV-1 and HIV-2 ribonuclease H

  1. Author:
    Dat, N. T.
    Bae, K.
    Wamiru, A.
    McMahon, J. B.
    Le Grice, S. F. J.
    Bona, M.
    Beutler, J. A.
    Kim, Y. H.

  2. Author Address

    Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea. NCI, Mol Targets Dev Program, HIV Drug Resistance Program, Frederick, MD 21702 USA. NCI, SAIC Frederick, Frederick, MD 21702 USA.;Kim, YH, Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea.;yhk@cnu.ac.kr
    1. Year: 2007
    2. Date: May
  2. Journal: Journal of Natural Products
    1. 70
    2. 5
    3. Pages: 839-841
  4. Type of Article: Article
  5. ISSN: 0163-3864
  1. Abstract:

    A new dimeric lactone, ardimerin digallate (1), was isolated from the whole plants of Ardisia japonica, along with six known constituents. The structure of 1 was established on the basis of spectroscopic analysis including 1D- and 2D-NMR techniques. Compound 1 inhibited HIV-1 and HIV-2 RNase H in vitro with IC50 values of 1.5 and 1.1 mu M, respectively.

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External Sources

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  2. DOI: 10.1021/np060359m
  3. View record in Web of Science®
  4. WOS: 000246764300022

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