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Tumor necrosis factor is critical to control tuberculosis infection

  1. Author:
    Jacobs, M.
    Togbe, D.
    Fremond, C.
    Samarina, A.
    Allie, N.
    Botha, T.
    Carlos, D.
    Parida, S. K.
    Grivennikov, S.
    Nedospasov, S.
    Monteiro, A.
    Le Bert, M.
    Quesniaux, V.
    Ryffel, B.

  2. Author Address

    CNRS, UMR 6218, Inst Transgenose, F-45071 Orleans, France. Univ Cape Town, Inst Infect Dis & Mol Med, ZA-7925 Cape Town, South Africa. NCI, Canc Res Ctr, Mol Immunoregulat Lab, Ft Detrick, MD 21702 USA. Cape Peninsula Univ Technol, Cape Town, South Africa. Russian Acad Sci, Engelhardt Inst Mol Biol, Lab Mol Immunol, Moscow 119991, Russia. Max Planck Inst, Berlin, Germany. Univ USP, Ribeirao Preto, Brazil.;Ryffel, B, CNRS, UMR 6218, Inst Transgenose, 3B Rue Ferollerie, F-45071 Orleans, France.;bryffel@cnrs-orleans.fr
    1. Year: 2007
    2. Date: Apr
  2. Journal: Microbes and Infection
    1. 9
    2. 5
    3. Pages: 623-628
  4. Type of Article: Review
  5. ISSN: 1286-4579
  1. Abstract:

    Tumor necrosis factor (TNF) is critical and non-redundant to control Mycobacterium tuberculosis infection and cannot be replaced by other proinflarnmatory cytokines. Overproduction of TNF may cause immunopathology, while TNF neutralization reactivates latent and chronic, controlled infection, which is relevant for the use of neutralizing TNF therapies in patients with rheumatoid arthritis. (c) 2007 Elsevier Masson SAS. All rights reserved.

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External Sources

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  2. DOI: 10.1016/j.micinf.2007.02.002
  3. View record in Web of Science®
  4. WOS: 000247107600010

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