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Lack of prognostic significance of prostate biopsies in metastatic androgen independent prostate cancer

  1. Author:
    Aragon-Ching, J. B.
    Gillespie, J.
    Price, D. K.
    Chuaqui, R.
    Rodriguez-Canales, J.
    Steinberg, S. M.
    Dahut, W. L.
    Figg, W. D.

  2. Author Address

    NCI, Med Oncol Branch, CCR, NIH, Bethesda, MD 20892 USA. NCI, Mol Pharmacol Sect, CCR, Bethesda, MD 20892 USA. NCI, Pathol Lab, CCR, Bethesda, MD 20892 USA. NCI, Biostat & Data Management Sect, CCR, Bethesda, MD 20892 USA. SAIC Frederick Inc, NCI, Frederick, MD USA.;Figg, WD, NCI, Med Oncol Branch, CCR, NIH, 900 Rockville Pikke,Bldg 10,Room 5A01, Bethesda, MD 20892 USA.;wdfigg@helix.nih.gov
    1. Year: 2007
    2. Date: Dec
  2. Journal: Bju International
    1. 100
    2. 6
    3. Pages: 1245-1248
  4. Type of Article: Article
  5. ISSN: 1464-4096
  1. Abstract:

    Objective To assess the significance of viable tumour in the prostate of patients with metastatic androgen-independent prostate cancer (AIPC). Patients and methods We evaluated the clinicopathological features, including follow-up, of 40 men with metastatic AIPC who had a transrectal biopsy of the prostate. Results Prostate biopsies (median three cores per biopsy) showed viable tumour in 19 of 40 patients (48%). Of the 18 patients who had received radiotherapy (RT), nine had negative on-study biopsy results. A previous history of RT was not associated with overall survival in patients with biopsy-positive tumours (P = 0.84). Also, there was no statistically significant association between positive or negative biopsy status and overall survival (OS) in these 40 patients (P = 0.39), with a similar median OS of 19.6 months for biopsy-negative and 19.8 months for biopsy-positive patients, respectively. Conclusions Taking prostate biopsies at the time of documented metastatic AIPC yielded tumour in about half the patients. A previous history of RT was not associated with a negative prostate biopsy; the latter appears to have no influence on the prognosis.

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  2. DOI: 10.1111/j.1464-410X.2007.07173.x
  3. View record in Web of Science®
  4. WOS: 000250552700013

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