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Cloning and Mapping of Cat (Felis Catus) Immunoglobulin and T-Cell Receptor Genes

  1. Author:
    Cho, K. W.
    Youn, H. Y.
    Okuda, M.
    Satoh, H.
    Cevario, S.
    Obrien, S. J.
    Watari, T.
    Tsujimoto, H.
    Hasegawa, A.
    1. Year: 1998
  2. Journal: Immunogenetics
    1. 47
    2. 3
    3. Pages: 226-233
  4. Type of Article: Article
  1. Abstract:

    Molecular cloning and chromosomal mapping of the cat immunoglobulin (Ig) and T-cell receptor (TcR) genes were carried out to provide basic information For genetic analysis of immunologic diseases including leukemias and lymphomas in cats. We cloned two ii: constant genes, IGHM and IGHG and three Ten constant genes, TRAC, TRGC, and TRDC, by polymerase chain reaction (FCR) amplification of cDNA from cat peripheral blood mononuclear cells. For chromosomal mapping of tile ip and TcR loci including the IGK, TC;I, and TRB on the cat genome, we performed PCR screening of DNAs li-om 37 cat x rodent somatic cell hybrids by using specific primers for the given genes, Consequently, three loci for IGH, TRA, and TRD, and two loci for TRB and TRG were found to be syntenic and assigned to cat chromosomes (FCA) B3 and A2, respectively. Further, IGK and IGL loci were mapped on FCA A3 and D3, respectively. These findings support the notion that the genetic linkages between the Ig and TcR genes are extensively conserved between humans and cats. [References: 41]

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