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Experimental validation for quantitative protein network models

  1. Author:
    Nishizuka, S.
    Spurrier, B.

  2. Author Address

    Nishizuka, Satoshi, Spurrier, Brett] NCI, Natl Inst Hlth, Ctr Canc Res, Mol Translat Technol Mol Therapeut Program, Bethesda, MD 20892 USA. [Nishizuka, Satoshi] SAIC Frederic Inc Frederick, Natl Canc Inst, Lab Proteom & Analyt Technol, Frederick, MD 21702 USA. [Nishizuka, Satoshi] Iwate Med Univ, Sch Med, Dept Surg, Morioka, Iwate 0208505, Japan.
    1. Year: 2008
  2. Journal: Current Opinion in Biotechnology
    1. 19
    2. 1
    3. Pages: 41-49
  4. Type of Article: Review
  1. Abstract:

    Cellular responses are the consequence of complex reactions of protein networks. The complexity should ultimately be described by a set of formulas in a quantitative fashion, in which each formula defines the reactions in response to given types of input. However, testing these formulas has not been a simple task because of the lack of appropriate means for experimental validation. 'Reverse-phase' lysate microarrays have been proved to be powerful for such requirements and thus can be a good resource for providing an experimental reference point for the theoretical biology of protein networks.

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External Sources

  1. PMID: 18187317

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