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Clinical Use of Interferon-gamma

  1. Author:
    Miller, C. H. T.
    Maher, S. G.
    Young, H. A.
    Donnelly, R. P.

  2. Author Address

    [Miller, Catriona H. T.; Young, Howard A.] NCI, Ctr Canc Res, Canc & Inflammat Program, Expt Immunol Lab, Frederick, MD 21702 USA. [Maher, Stephen G.] St James Hosp, Trinity Coll Dublin, Dept Surg, Trinity Ctr Hlth Sci, Dublin 8, Ireland.;Young, HA, NCI, Ctr Canc Res, Canc & Inflammat Program, Expt Immunol Lab, Bldg 560 RM31-16, Frederick, MD 21702 USA.;younghow@mail.nih.gov
    1. Year: 2009
  2. Book Title: Cytokine Therapies: Novel Approaches for Clinical Indications
  3. Series Title: Annals of the New York Academy of Sciences
  4. Blackwell Publishing
  5. Oxford
    1. 1182
    2. Pages: 69-79
  7. Type of Work: Proceedings Paper; Review
  8. ISBN: 0077-8923;978-1-57331-783-2
  1. Abstract:

    Interferon gamma (IFN-gamma), a pleotropic cytokine, has been shown to be important to the function of virtually all immune cells and both innate and adaptive immune responses. In 1986, early clinical trials of this cytokine began to evaluate its therapeutic potential. The initial studies focused on the tolerability and pharmacology of IFN-gamma and systematically determined its antitumor and anti-infection activities. In the 20-plus years since those first trials, IFN-gamma has been used in a wide variety of clinical indications, which are reviewed in this article.

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External Sources

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  2. DOI: 10.1111/j.1749-6632.2009.05069.x
  3. PMID: 20074276
  4. View record in Web of Science®
  5. WOS: 000277730400007

Library Notes

  1. Fiscal Year: FY2009-2010
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