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IgM, not IgG, a key for HIV vaccine

  1. Author:
    Yang, Q. E.
    1. Year: 2009
  2. Journal: Vaccine
    1. 27
    2. 9
    3. Pages: 1287-1288
  4. Type of Article: Letter
  1. Abstract:

    Although HIV infections induce a very strong humoral immune reaction with various neutralization activities and a well-defined cellular immunity, HIV vaccine development based oil traditional approaches failed. The fact that neither specific antibodies nor activated CD8(+) cytotoxicity T-cells could provide primary protection in high risk populations raises the question concerning whether a specific vaccine is feasible. While the immune system as an intact defense system against HIV is ineffective or may even enhance the virus spread, a distinct small part of the system plays important role in delaying the progress of the disease. After carefully dissecting the different immune reactions against the virus, a new HIV vaccine strategy is indicated. (C) 2008 Elsevier Ltd. All rights reserved.

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External Sources

  1. PMID: 19146899

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