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DNA Methylation in Early Development

  1. Author:
    Geiman, T. M.
    Muegge, K.

  2. Author Address

    [Geiman, Theresa M.; Muegge, Kathrin] NCI, Lab Canc Prevent, SAIC Frederick, Frederick, MD 21702 USA.;Geiman, TM, NCI, Lab Canc Prevent, SAIC Frederick, Bldg 560,Rm 12-25, Frederick, MD 21702 USA.;geimant@ncifcrf.gov
    1. Year: 2010
    2. Date: Feb
  2. Journal: Molecular Reproduction and Development
    1. 77
    2. 2
    3. Pages: 105-113
  4. Type of Article: Review
  5. ISSN: 1040-452X
  1. Abstract:

    Development from separate parental germ cells through fertilization and proceeding to a fully functioning adult animal occurs through an intricate program of transcriptional and chromatin changes. Epigenetic alterations such as DNA methylation are an important part of this process. This review looks at the role of DNA methylation in early embryonic development, as well as how this epigenetic mark affects stem cell differentiation and tissue-specific gene expression in somatic cells.

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External Sources

  1. View Full Text
  2. DOI: 10.1002/mrd.21118
  3. View record in Web of Science®
  4. WOS: 000273518200004

Library Notes

  1. Fiscal Year: FY2009-2010
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