Skip NavigationSkip to Content
Return Return to Search Results

A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33

  1. Author:
    Petersen, G. M.
    Amundadottir, L.
    Fuchs, C. S.
    Kraft, P.
    Stolzenberg-Solomon, R. Z.
    Jacobs, K. B.
    Arslan, A. A.
    Bueno-de-Mesquita, H. B.
    Gallinger, S.
    Gross, M.
    Helzlsouer, K.
    Holly, E. A.
    Jacobs, E. J.
    Klein, A. P.
    LaCroix, A.
    Li, D. H.
    Mandelson, M. T.
    Olson, S. H.
    Risch, H. A.
    Zheng, W.
    Albanes, D.
    Bamlet, W. R.
    Berg, C. D.
    Boutron-Ruault, M. C.
    Buring, J. E.
    Bracci, P. M.
    Canzian, F.
    Clipp, S.
    Cotterchio, M.
    de Andrade, M.
    Duell, E. J.
    Gaziano, J. M.
    Giovannucci, E. L.
    Goggins, M.
    Hallmans, G.
    Hankinson, S. E.
    Hassan, M.
    Howard, B.
    Hunter, D. J.
    Hutchinson, A.
    Jenab, M.
    Kaaks, R.
    Kooperberg, C.
    Krogh, V.
    Kurtz, R. C.
    Lynch, S. M.
    McWilliams, R. R.
    Mendelsohn, J. B.
    Michaud, D. S.
    Parikh, H.
    Patel, A. V.
    Peeters, P. H. M.
    Rajkovic, A.
    Riboli, E.
    Rodriguez, L.
    Seminara, D.
    Shu, X. O.
    Thomas, G.
    Tjonneland, A.
    Tobias, G. S.
    Trichopoulos, D.
    Van Den Eeden, S. K.
    Virtamo, J.
    Wactawski-Wende, J.
    Wang, Z. M.
    Wolpin, B. M.
    Yu, H.
    Yu, K.
    Zeleniuch-Jacquotte, A.
    Fraumeni, J. F.
    Hoover, R. N.
    Hartge, P.
    Chanock, S. J.

  2. Author Address

    [Amundadottir, Laufey; Parikh, Hemang; Chanock, Stephen J.] NCI, Lab Translat Genom, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, Bethesda, MD 20892 USA. [Petersen, Gloria M.; Bamlet, William R.; de Andrade, Mariza; McWilliams, Robert R.] Mayo Clin, Coll Med, Dept Hlth Sci Res, Rochester, MN USA. [Fuchs, Charles S.; Wolpin, Brian M.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. [Fuchs, Charles S.; Giovannucci, Edward L.; Hankinson, Susan E.; Hunter, David J.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Channing Lab,Dept Med, Boston, MA 02115 USA. [Giovannucci, Edward L.; Hankinson, Susan E.; Hunter, David J.; Michaud, Dominique S.; Trichopoulos, Dimitrios] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. [Kraft, Peter] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA. [Jacobs, Kevin B.; Hutchinson, Amy; Wang, Zhaoming] NCI, Core Genotyping Facil, SAIC Frederick Inc, Frederick, MD 21701 USA. [Jacobs, Kevin B.] Bioinformed Consulting Serv, Gaithersburg, MD USA. [Arslan, Alan A.] NYU, Sch Med, Dept Obstet & Gynecol, New York, NY USA. [Arslan, Alan A.; Zeleniuch-Jacquotte, Anne] NYU, Sch Med, Dept Environm Med, New York, NY USA. [Arslan, Alan A.; Zeleniuch-Jacquotte, Anne] NYU, Inst Canc, New York, NY USA. [Bueno-de-Mesquita, H. Bas] Natl Inst Publ Hlth & Environm, RIVM, NL-3720 BA Bilthoven, Netherlands. [Bueno-de-Mesquita, H. Bas] Univ Med Ctr Utrecht, Dept Gastroenterol & Hepatol, Utrecht, Netherlands. [Gallinger, Steven] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada. [Gross, Myron] Univ Minnesota, Dept Lab Med & Pathol, Sch Med, Minneapolis, MN 55455 USA. [Helzlsouer, Kathy] Mercy Med Ctr, Prevent & Res Ctr, Baltimore, MD USA. [Holly, Elizabeth A.; Bracci, Paige M.] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA. [Jacobs, Eric J.; Patel, Alpa V.] Amer Canc Soc, Dept Epidemiol, Atlanta, GA 30329 USA. [Klein, Alison P.] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA. [Klein, Alison P.] Johns Hopkins Med Inst, Sol Goldman Pancreat Res Ctr, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA. [LaCroix, Andrea; Mandelson, Margaret T.; Kooperberg, Charles] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA. [Li, Donghui; Hassan, Manal] Univ Texas MD Anderson Canc Ctr, Dept Gastrointestinal Med Oncol, Houston, TX 77030 USA. [Mandelson, Margaret T.] Grp Hlth Ctr Hlth Studies, Seattle, WA USA. [Olson, Sara H.] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA. [Risch, Harvey A.; Yu, Herbert] Yale Univ, Sch Publ Hlth, New Haven, CT USA. [Zheng, Wei; Shu, Xiao-Ou] Vanderbilt Univ, Dept Med, Nashville, TN USA. [Zheng, Wei; Shu, Xiao-Ou] Vanderbilt Univ, Vanderbilt Ingram Canc Ctr, Nashville, TN USA. [Berg, Christine D.] NCI, Canc Prevent Div, NIH, Bethesda, MD 20892 USA. [Boutron-Ruault, Marie-Christine] Univ Paris Sud, INSERM, Inst Gustave Roussy, Villejuif, France. [Buring, Julie E.] Brigham & Womens Hosp, Dept Med, Div Prevent Med, Boston, MA 02115 USA. [Buring, Julie E.] Brigham & Womens Hosp, Dept Med, Dept Aging, Boston, MA 02115 USA. [Buring, Julie E.] Harvard Univ, Sch Med, Dept Ambulatory Care & Prevent, Boston, MA USA. [Canzian, Federico] German Canc Res Ctr, Heidelberg, Germany. [Clipp, Sandra] George W Comstock Ctr Publ Hlth Res & Prevent, Johns Hopkins Bloomberg Sch Publ Hlth, Hagerstown, MD USA. [Cotterchio, Michelle] Univ Toronto, Canc Care Ontario & Dalla Lana Sch Publ Hlth, Toronto, ON, Canada. [Duell, Eric J.] Catalan Inst Oncol, Barcelona, Spain. [Gaziano, J. Michael] Brigham & Womens Hosp, Phys Hlth Study, Div Aging, Dept Med, Boston, MA 02115 USA. [Gaziano, J. Michael] Brigham & Womens Hosp, Phys Hlth Study, Div Cardiovasc Dis, Dept Med, Boston, MA 02115 USA. [Gaziano, J. Michael] Brigham & Womens Hosp, Phys Hlth Study, Div Prevent Med, Dept Med, Boston, MA 02115 USA. [Gaziano, J. Michael] Vet Affairs Boston Healthcare Syst, Massachusetts Vet Epidemiol Res & Informat Ctr, Boston, MA USA. [Giovannucci, Edward L.] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA. [Goggins, Michael] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA. [Goggins, Michael] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA. [Goggins, Michael] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA. [Hallmans, Goran] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden. [Howard, Barbara] Georgetown Univ, MedStar Res Inst, Hyattsville, MD USA. [Krogh, Vittorio] Fdn IRCCS, Ist Nazl Tumoridi Milano, Nutr Epidemiol Unit, Milan, Italy. [Kurtz, Robert C.] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10021 USA. [Lynch, Shannon M.; Seminara, Daniela] NCI, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA. [Michaud, Dominique S.; Peeters, Petra H. M.; Riboli, Elio] Univ London Imperial Coll Sci Technol & Med, Div Epidemiol Publ Hlth & Primary Care, London, England. [Peeters, Petra H. M.] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands. [Rajkovic, Aleksandar] Univ Pittsburgh, Dept Obstet Gynecol & Reprod Biol, Pittsburgh, PA USA. [Rodriguez, Laudina] Hlth & Hlth Care Serv Council, Publ Hlth & Participat Directorate, Asturias, Spain. [Thomas, Gilles] Ctr Leon Berard, INSERM, F-69373 Lyon, France. [Tjonneland, Anne] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark. [Trichopoulos, Dimitrios] Acad Athens, Bur Epidemiol Res, Athens, Greece. [Van Den Eeden, Stephen K.] Kaiser Permanente, Div Res, Oakland, CA USA. [Virtamo, Jarmo] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland. [Wactawski-Wende, Jean] SUNY Buffalo, Dept Social & Prevent Med, Buffalo, NY 14260 USA.;Chanock, SJ, NCI, Lab Translat Genom, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, Bethesda, MD 20892 USA.;chanocks@mail.nih.gov
    1. Year: 2010
    2. Date: Mar
  2. Journal: Nature Genetics
    1. 42
    2. 3
    3. Pages: 224-U29
  4. Type of Article: Article
  5. ISSN: 1061-4036
  1. Abstract:

    We conducted a genome-wide association study of pancreatic cancer in 3,851 affected individuals (cases) and 3,934 unaffected controls drawn from 12 prospective cohort studies and 8 case-control studies. Based on a logistic regression model for genotype trend effect that was adjusted for study, age, sex, self-described ancestry and five principal components, we identified eight SNPs that map to three loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Two correlated SNPs, rs9543325 (P = 3.27 x 10(-11), per-allele odds ratio (OR) 1.26, 95% CI 1.18-1.35) and rs9564966 (P = 5.86 x 10(-8), per-allele OR 1.21, 95% CI 1.13-1.30), map to a nongenic region on chromosome 13q22.1. Five SNPs on 1q32.1 map to NR5A2, and the strongest signal was at rs3790844 (P = 2.45 x 10(-10), per-allele OR 0.77, 95% CI 0.71-0.84). A single SNP, rs401681 (P = 3.66 x 10(-7), per-allele OR 1.19, 95% CI 1.11-1.27), maps to the CLPTM1L-TERT locus on 5p15.33, which is associated with multiple cancers. Our study has identified common susceptibility loci for pancreatic cancer that warrant follow-up studies.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1038/ng.522
  3. View record in Web of Science®
  4. WOS: 000274912400010

Library Notes

  1. Fiscal Year: FY2009-2010
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel