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JAK-STAT Is Restrained by Notch to Control Cell Proliferation of the Drosophila Intestinal Stem Cells

  1. Author:
    Liu, W.
    Singh, S. R.
    Hou, S. X.

  2. Author Address

    [Liu, Wei; Singh, Shree Ram; Hou, Steven X.] NCI, Mouse Canc Genet Program, NIH, Frederick, MD 21702 USA.;Liu, W, NCI, Mouse Canc Genet Program, NIH, Bldg 560,Room 12-70, Frederick, MD 21702 USA.;weiliu@mail.nih.gov
    1. Year: 2010
    2. Date: Apr
  2. Journal: Journal of Cellular Biochemistry
    1. 109
    2. 5
    3. Pages: 992-999
  4. Type of Article: Article
  5. ISSN: 0730-2312
  1. Abstract:

    The Drosophila midgut epithelium undergoes continuous regeneration that is sustained by multipotent intestinal stem cells (ISCs) underneath. Notch signaling has dual functions to control ISC behavior: it slows down the ISC proliferation and drives the activated ISCs into different differentiation pathways at a dose-dependent manner. Here we identified a molecular mechanism to unite these two contradictory functions. We found JAK-STAT signaling controls ISC proliferation and this ability is negatively regulated by Notch at least through a transcriptional control of the JAK-STAT signaling ligand, unpaired (upd). This study provides insight into how stem cells, under steady conditions, balance the processes of proliferation and differentiation to maintain the stable cellular composition of a healthy tissue. J. Cell. Biochem. 109: 992999, 2010. (C) 2010 Wiley-Liss, Inc.

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External Sources

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  2. DOI: 10.1002/jcb.22482
  3. View record in Web of Science®
  4. WOS: 000276418900019

Library Notes

  1. Fiscal Year: FY2009-2010
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