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Antitumor activity and COMPARE analysis of bis-indole derivatives

  1. Author:
    Andreani, A.
    Burnelli, S.
    Granaiola, M.
    Leoni, A.
    Locatelli, A.
    Morigi, R.
    Rambaldi, M.
    Varoli, L.
    Landi, L.
    Prata, C.
    Dalla Sega, F. V.
    Caliceti, C.
    Shoemaker, R. H.

  2. Author Address

    [Andreani, Aldo; Burnelli, Silvia; Granaiola, Massimiliano; Leoni, Alberto; Locatelli, Alessandra; Morigi, Rita; Rambaldi, Mirella; Varoli, Lucilla] Univ Bologna, Dipartimento Sci Farmaceut, I-40126 Bologna, Italy. [Landi, Laura; Prata, Cecilia; Dalla Sega, Francesco Vieceli; Caliceti, Cristiana] Univ Bologna, Dipartimento Biochim G Moruzzi, I-40126 Bologna, Italy. [Shoemaker, Robert H.] NCI, Div Canc Treatment & Diag, Screening Technol Branch, Dev Therapeut Program, Frederick, MD 21702 USA.;Andreani, A, Univ Bologna, Dipartimento Sci Farmaceut, Via Belmeloro 6, I-40126 Bologna, Italy.;aldo.andreani@unibo.it
    1. Year: 2010
    2. Date: May
  2. Journal: Bioorganic & Medicinal Chemistry
    1. 18
    2. 9
    3. Pages: 3004-3011
  4. Type of Article: Article
  5. ISSN: 0968-0896
  1. Abstract:

    This paper reports the synthesis of new derivatives (formed by two indole systems separated by a central moiety) analogous of potent antitumor agents previously described. The activity of the bis-indoles bearing a pyridine core confirms the good result described in the previous paper and compound 4c was chosen for the first in vivo experiment (Hollow Fiber Assay). COMPARE analysis and structure-activity relationships were also considered. Contrary to data reported by other Authors, no correlations were found between antitumor activity and NQO1 induction. (c) 2010 Elsevier Ltd. All rights reserved.

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.bmc.2010.03.063
  3. View record in Web of Science®
  4. WOS: 000277083400002

Library Notes

  1. Fiscal Year: FY2009-2010
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